Effectiveness of early initiation of protease inhibitor-sparing antiretroviral regimen in human immunodeficiency virus-1 vertically infected infants.
(2007) The Pediatric Infectious Disease Journal — Vol. 26, n° 4, p. 359-361 (2007)
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- Abstract
- Each of the 17 vertically infected infants born to HIV-1-infected mothers in Belgian HIV reference centers since 1996 was treated with a combination of 3 reverse transcription inhibitors as soon as the diagnosis was established. Treatment was initiated in all patients before 66 days of life. Twelve patients, including 11/13 infants treated with the combination of zidovudine, lamivudine and nevirapine, experienced a complete viral suppression (<50 copies/mL) with their first drug regimen. At last follow-up, 12 patients were asymptomatic, 2 were CDC stage A and 3 were stage B; 15 had HIV-1 RNA levels of <50 copies/mL and 14 had >or=25% CD4 lymphocytes. These results suggest that early initiation of treatment with 3 reverse transcription inhibitors is highly effective to inhibit viral replication and to prevent clinical and immunologic progression of HIV infection in vertically infected infants.
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Citations
Van der Linden, D., Hainaut, M., Goetghebuer, T., Haelterman, E., Schmitz, V., Maes, P., Peltier, A., & Levy, J. (2007). Effectiveness of early initiation of protease inhibitor-sparing antiretroviral regimen in human immunodeficiency virus-1 vertically infected infants. The Pediatric Infectious Disease Journal, 26(4), 359-361. https://doi.org/10.1097/01.inf.0000258626.34984.eb (Original work published 2007)