Low cholesterol levels are associated with a high mortality risk in older adults without statins therapy: An externally validated cohort study
(2020) Archives of Gerontology and Geriatrics — Vol. 90, p. 104180 (2020)
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- Authors
Turusheva, Anna 
Vaes, Bert Degryse, Jean-Marie Frolova, Elena
- Abstract
- Background: The relationship of total cholesterol (TC) levels with mortality among older adults without statin therapy has not been fully studied. Aims: To examine the relationship between TC and all-cause mortality in adults aged 65 years and older in Russia without statin therapy. Methods: This was a population-based prospective cohort study of community-dwelling people aged 65 years and older in Russia. Data from 379 individuals on cardiovascular risk factors; comorbidities; cognitive, physical and autonomous function; lipid panel; B-type natriuretic peptide; C-reactive protein; and others were collected through interviews, clinical examinations, and laboratory tests. The total follow-up time was 3 years. Cox proportional hazards models for all-cause mortality, C-statistics, internal validation and external validation using the Belgian population from the BELFRAIL study were performed. Results: A U-shaped association between the TC level and all-cause mortality was identified. Older adults without statin therapy and with low/high TC levels were at higher risk for mortality even after adjustment for covariates, with a hazard ratio (HR) of 5.78 (1.96–17.03) for TC < 5.4 mmol/L and an HR of 6.24 (1.69–22.94) for TC levels>7.2 mmol/L. The association between low TC and all-cause mortality was confirmed in an external population of adults 80 years and older. Conclusion: The TC level range associated with the lowest mortality was 5.4–7.2 mmol/L, irrespective of concomitant diseases or health status. The association between low TC levels and a high risk of all-cause mortality was confirmed in a Belgian cohort of adults 80 years and older.
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Citations
Turusheva, A., Vaes, B., Degryse, J.-M., & Frolova, E. (2020). Low cholesterol levels are associated with a high mortality risk in older adults without statins therapy: An externally validated cohort study. Archives of Gerontology and Geriatrics, 90, 104180. https://doi.org/10.1016/j.archger.2020.104180 (Original work published 2020)