Interleukin-2 in the pathogenesis of perinatal white matter damage.
(2002) Neurology — Vol. 58, n° 7, p. 1125-1128 (2002)
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- Abstract
- Proinflammatory cytokines were reported to be implicated in the pathogenesis of perinatal white matter lesions. The authors document for the first time the in situ detection of interleukin-2 and interleukin-2 receptor (IL-2R) in these human white matter lesions. These results suggest that interleukin-2, reported to be toxic to oligodendrocytes and myelin, could play a role in the molecular cascade leading to white matter damage in periventricular leukomalacia.
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Citations
Kadhim, H., Tabarki, B., De Prez, C., Rona, A.-M., & Sébire, G. (2002). Interleukin-2 in the pathogenesis of perinatal white matter damage. Neurology, 58(7), 1125-1128. https://doi.org/10.1212/WNL.58.7.1125 (Original work published 2002)