MiR-199a family members : new actors of cardiovascular functions in health and disease
(2020)
Files
ThèsefinaleJorisV110820.pdf
Open Access - Adobe PDF
- 5.43 MB
Details
- Authors
- Supervisors
- Dessy, Chantal
- Abstract
- Endothelial cells play an important role in cardiovascular function and in the response to cardiac pathologies. This work studies the role of miR-199a-3p and -5p in endothelial and cardiac cells and their impact on the vascular function. Our results show that miR-199a family members modulate NO bioavailability and endothelial function. In the same line, cardiac hypertrophy induced by exercise decreases miR-199a expression while pathological cardiac hypertrophy induced by transaortic constriction increases it. This conditions are correlated with a modulation of endothelial function. Furthermore we show that AMPKa1 is implicated in the stabilization of miR-199a-5p during pathological cardiac hypertrophy. In summary, our results demonstrated that miR-199a family members are key players of cardiac and endothelial functions at the crossroad of health and disease.
- Affiliations
UCLouvain SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique
Citations
Joris, V. (2020). MiR-199a family members : new actors of cardiovascular functions in health and disease. https://hdl.handle.net/2078.5/24927