Muconic acid in urine: a reliable indicator of occupational exposure to benzene

Lauwerys, Robert;Buchet, Jean-Pierre;Andrien, Fabian
(1994) American Journal of Industrial Medicine — Vol. 25, n° 2, p. 297-300 (1994)

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Authors
  • Lauwerys, RobertUCLouvain
    Author
  • Buchet, Jean-PierreUCLouvain
    Author
  • Andrien, Fabian
    Author
Abstract
In male subjects not occupationally exposed to benzene, the concentration of muconic acid (MA) in urine is usually below 0.5 mg/g creatinine. At ambient levels of benzene exposure (below 0.01 ppm), the mean MA level was greater in 21 smokers than in 14 nonsmokers. In 38 male subjects employed in garages and coke ovens, a statistically significant correlation was found between the airborne concentration of benzene measured with passive monitors and MA in postshift urine. The mean postshift MA concentrations corresponding to a benzene 8-hour time-weighted average exposure (TWA) of 0.5 and 1 ppm were 0.8 and 1.4 mg/g creatinine, respectively.
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Lauwerys, R., Buchet, J.-P., & Andrien, F. (1994). Muconic acid in urine: a reliable indicator of occupational exposure to benzene. American Journal of Industrial Medicine, 25(2), 297-300. https://doi.org/10.1002/ajim.4700250216 (Original work published 1994)