A promoting effect of portocaval anastomosis in a triphasic model of rat hepatocarcinogenesis is demonstrated since after initiation and selection premalignant lesions and hepatocellular carcinomas increase. This demonstrates that chronic administration of an exogenous compound is not the only way to promote cancer development.
Préat, V., Pector, J. C., Taper, H., de Gerlache, J., Lans, M., & Roberfroid, M. (1984). Effet promoteur de l’anastomose portocave dans l’hépatocarcinogenèse expérimentale. Societe de Biologie et de Ses Filiales. Comptes Rendus des Seances, 178(4), 408-413. https://hdl.handle.net/2078.5/52911 (Original work published 1984)