Chiral resolution of racemic ibuprofen sodium via diastereomeric ionic cocrystallization with proline
(2026) Chemical Communications — Vol. 62, n° 32, p. 8280-8283 (2026)
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- Abstract
- Diasteriomeric ionic cocrystallization is introduced as a novel crystallization-based resolution tool. RS-Ibuprofen sodium is succesfully resolved using proline as a resolution agent, achieving ee > 90% in a single resolution step. This work, for the first time, demonstrates diastereomeric ionic cocrystallization as a powerful approach to chiral resolution.
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Citations
Wen, T., Robeyns, K., Collard, L., Leyssens, T., & Leng, F. (2026). Chiral resolution of racemic ibuprofen sodium via diastereomeric ionic cocrystallization with proline. Chemical Communications, 62(32), 8280-8283. https://doi.org/10.1039/D6CC01175F (Original work published 2026)