Development and characterization of endocannabinoid hydrolases FAAH and MAGL inhibitors bearing a benzotriazol-1-yl carboxamide scaffold

Morera, Ludovica;Labar, Geoffray;Ortar, Giorgio;Lambert, Didier
(2012) Bioorganic & Medicinal Chemistry : the tetrahedron journal for research at the interface of chemistry and biology — Vol. 20, n° 21, p. 6260-6275 (2012)

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Authors
  • Morera, Ludovica
    Author
  • Labar, GeoffrayUCLouvain
    Author
  • Ortar, Giorgio
    Author
  • Lambert, Didierorcid-logoUCLouvain
    Author
Abstract
A series of (1H-benzo[d][1,2,3]triazol-1-yl)(4-benzylpiperazin-1-yl) methanones and of (1H-benzo[d][1,2,3]triazol-1-yl)(4-phenylpiperazin-1-yl) methanones has been prepared and tested on human fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). In the benzylpiperazinyl series, compound 29 (ML30) exhibited an IC<inf>50</inf> value of 0.54 nM on MAGL, combined with a 1000-fold selectivity versus FAAH, while compounds 11 and 16 acted as potent dual FAAH-MAGL inhibitors (IC<inf>50</inf> &lt;10 nM). In the phenylpiperazinyl series, compounds 37, 38, 42, and 43 displayed IC<inf>50</inf> values against MAGL in the nanomolar range, whilst being between one and two orders of magnitude less potent on the FAAH, while compounds 31 and 32 were potent FAAH inhibitors (IC<inf>50</inf> &lt;20 nM) and over 12-fold selective versus MAGL. The key structural determinants driving the structure-activity relationships were explored by the minimization of the inhibitors inside the active site of both enzymes. © 2012 Elsevier Ltd. All rights reserved.
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Morera, L., Labar, G., Ortar, G., & Lambert, D. (2012). Development and characterization of endocannabinoid hydrolases FAAH and MAGL inhibitors bearing a benzotriazol-1-yl carboxamide scaffold. Bioorganic & Medicinal Chemistry : the tetrahedron journal for research at the interface of chemistry and biology, 20(21), 6260-6275. https://doi.org/10.1016/j.bmc.2012.09.011 (Original work published 2012)