A synthetic route towards cyclopropylic compounds, which act as glucokinase activators is described herein. The present synthesis gives easy and rapid access to a wide variety of either sulfones or sulfonamides starting from readily available late-stage intermediates. (c) 2006 Elsevier Ltd. All rights reserved.
Heuser, S., Barrett, D., Berg, M., Bonnier, B., Kahl, A., De la Puente, M., Oram, N., Riedl, R., Roettig, U., Gil, G., Seger, E., Steggles, D., Wanner, J., & Weichert, A. (2006). Synthesis of novel cyclopropylic sulfones and sulfonamides acting as glucokinase activators. Tetrahedron Letters, 47(16), 2675-2678. https://doi.org/10.1016/j.tetlet.2006.02.110 (Original work published 2006)