Synthesis of secretory component by rat hepatocytes in culture.
(1980) Scandinavian Journal of Immunology — Vol. 11, n° 1, p. 93-97 (1980)
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- Normal rat hepatocytes were isolated and cultivated in vitro. Synthesis of secretory component was demonstrated by its accumulation in the culture medium, as measured by radioimmunoassay; by incorporation of 14C-leucine in the protein specifically precipitated with anti-secretory component antiserum; and by a positive precipitin reaction of concentrated culture medium with the same antiserum. The results explain the high levels of secretory component found in rat bile and render plausible a mechanism of hepatic IgA transfer involving secretory component as the hepatocyte membrane receptor for polymeric IgA.
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Zevenbergen, J. L., May, C., Wanson, J. C., & Vaerman, J.-P. (1980). Synthesis of secretory component by rat hepatocytes in culture. Scandinavian Journal of Immunology, 11(1), 93-97. https://hdl.handle.net/2078.5/52897 (Original work published 1980)