Reduction of the dose to the elective neck in head and neck squamous cell carcinoma, a randomized clinical trial using intensity modulated radiotherapy (IMRT). Dosimetrical analysis and effect on acute toxicity

Nuyts, S.;Lambrecht, M.;Duprez, F.;Daisne, Jean-François;De Neve, W.;et.al.
(2013) Radiotherapy & Oncology — Vol. 109, n° 2, p. 323-329 (2013)

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Authors
  • Nuyts, S.
    Author
  • Lambrecht, M.
    Author
  • Duprez, F.
    Author
  • Daisne, Jean-FrançoisMGD
    Author
  • De Neve, W.
    Author
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Abstract
Background and purpose A randomized trial was initiated to investigate whether a reduction of the dose to the elective nodal sites and the swallowing apparatus delivered by IMRT would result in a reduction of acute and late side effects without compromising tumor control. The aim of this paper is to report on dosimetrical analysis and acute toxicity. Materials & methods Two-hundred patients were randomized. In the standard arm, elective nodal volumes (PTV elect) were irradiated up to an equivalent dose of 50 Gy. In the experimental arm an equivalent dose of 40 Gy was prescribed to the PTV elect. The dose to the swallowing apparatus was kept as low as possible without compromising therapeutic PTV (PTVther) coverage. Results No significant difference was seen between both arms concerning PTV ther coverage. The median D95 of the PTVelect was significantly lower in the experimental arm (39.5 vs 49.8 Gy; p < 0.001). Concerning the organs at risk, the dose to swallowing structures and spinal cord was significantly reduced. There was no significant difference in acute toxicity. Three months after radiotherapy there was significantly less grade ≥3 dysphagia in the experimental arm (2% vs 11%; p = 0.03). With a median follow-up of 6 months no significant differences were observed in locoregional control, disease free survival or overall survival. Conclusions Using IMRT we were able to significantly reduce the dose to the PTVelect and several organs at risk without compromising PTVther coverage. This resulted in a significant reduction of severe dysphagia 3 months after radiotherapy. Further follow-up is necessary to investigate whether these observations translate into a benefit on late treatment related dysphagia without affecting treatment outcome. © 2013 Elsevier Ireland Ltd. All rights reserved.
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Nuyts, S., Lambrecht, M., Duprez, F., Daisne, J.-F., Van Gestel, D., Van Den Weyngaert, D., Platteaux, N., Geussens, Y., Voordeckers, M., Madani, I., & De Neve, W. (2013). Reduction of the dose to the elective neck in head and neck squamous cell carcinoma, a randomized clinical trial using intensity modulated radiotherapy (IMRT). Dosimetrical analysis and effect on acute toxicity. Radiotherapy & Oncology, 109(2), 323-329. https://doi.org/10.1016/j.radonc.2013.06.044 (Original work published 2013)