Improving the biological and physical targeting of radiation therapy in lung tumours
(2018)
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- Abstract
- Despite recent technological advancements in the field of radiation therapy, the treatment results remain disappointing in patients with locally-advanced lung cancer, which experience high rates of local tumour relapse. Hopefully, improvements might come from better biological targeting of the treatment. Notably, the dose painting (DP) strategy is particularly promising. This approach aims at identifying the most radioresistant tumour regions through functional imaging (e.g. PET imaging) in order to specifically target them with higher radiation dose. In this framework, we analysed, for two of the most promising PET tracers in the context of DP (18F-FDG and 18F-FAZA), the stability and the distinctiveness of their uptake patterns during treatment. Obviously, biological tailoring only makes sense if it is coupled to correct physical targeting. In particular, one of the main obstacles hampering precise targeting of lung tumours is the tumour motion associated with respiration. In this context, we evaluated the use of non-invasive methods, such as the administration of continuous positive airway pressure (CPAP), as a way of modulating breathing motion.
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Di Perri, D. (2018). Improving the biological and physical targeting of radiation therapy in lung tumours. https://hdl.handle.net/2078.5/175876