Vascular memory, from old concepts to a new model : sustained down-regulation of alpha-Smooth Muscle Actin induced by Angiotensin II
(2022)
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- Authors
- Supervisors
- Balligand, Jean-Luc
- Abstract
- In medicine, a legacy effect is defined as the sustained beneficial effect of a given treatment on disease outcomes, even after cessation of the intervention. Initially described in optimized control of diabetes, it was also observed in clinical trials exploring intensification strategies for other cardiovascular risk factors, such as hypertension or hypercholesterolemia. Mechanisms of legacy were particularly deciphered in diabetes, leading to the concept of metabolic memory. Interestingly, epigenetic changes and reactive oxygen species (ROS) appear to be common features of “memory” of the vascular wall. In this thesis project, we developed an original model of “hypertension memory” in which we observed long term legacy effect on cardiovascular tissue of transient hypertension induced by Angiotensin II, and identified some regulators of this memory, including epigenetic modification. These data open the way for further understanding of legacy effect of cardiovascular risk factors on vascular tissue, and to further therapeutics possibilities to erase this memory.
- Affiliations
Citations
Pothen, L. (2022). Vascular memory, from old concepts to a new model : sustained down-regulation of alpha-Smooth Muscle Actin induced by Angiotensin II. https://hdl.handle.net/2078.5/105772