Mycothiol/mycoredoxin 1-dependent reduction of the peroxiredoxin AhpE from mycobacterium tuberculosis

Hugo, Martín;Trujillo, Madia;Radi, Rafael;Messens, Joris;Van Laer, Koen;et.al.
(2014) Journal of Biological Chemistry — Vol. 289, n° 8, p. 5228-5239 (2014)

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Authors
  • Hugo, Martín
    Author
  • Trujillo, Madia
    Author
  • Radi, Rafael
    Author
  • Messens, Joris
    Author
  • Vertommen, Didierorcid-logoUCLouvain
    Author
  • Van Laer, Koen
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Abstract
Background: Mycothiol, the major low-molecular weight thiol of Mycobacterium tuberculosis, is important for peroxide detoxification and virulence. Results: Mycothiol, together with mycoredoxin-1, a glutaredoxin-like protein, reduces the one-cysteine peroxiredoxin AhpE from the bacterium. Conclusion: Mycobacterium tuberculosis AhpE is a mycothiol/mycoredoxin-1- dependent peroxidase. Significance: Our results provide the first molecular link between a thiol-dependent peroxidase and the mycothiol/mycoredoxin- 1 pathway in Mycobacteria. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
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Hugo, M., Trujillo, M., Radi, R., Messens, J., Vertommen, D., Reyes, A. M., & Van Laer, K. (2014). Mycothiol/mycoredoxin 1-dependent reduction of the peroxiredoxin AhpE from mycobacterium tuberculosis. Journal of Biological Chemistry, 289(8), 5228-5239. https://doi.org/10.1074/jbc.M113.510248 (Original work published 2014)