Antibody-functionalized gold nanoparticles as tumor targeting radiosensitizers for proton therapy.
(2019) Nanomedicine (London, England) — Vol. 14, p. 317-333 (2019)
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- This study aimed at developing antibody-functionalized gold nanoparticles (AuNPs) to selectively target cancer cells and probing their potential radiosensitizing effects under proton irradiation. AuNPs were conjugated with cetuximab (Ctxb-AuNPs). Ctxb-AuNP uptake was evaluated by transmission electron microscopy and atomic absorption spectroscopy. Radioenhancing effect was assessed using conventional clonogenic assay. Ctxb-AuNPs specifically bound to and accumulated in EGFR-overexpressing A431 cells, compared with EGFR-negative MDA-MB-453 cells. Ctxb-AuNPs enhanced the effect of proton irradiation in A431 cells but not in MDA-MB-453 cells. These data indicate, for the first time, that combining enhanced uptake by specific targeting and radioenhancing effect, using conjugated AuNPs, is a promising strategy to increase cell killing by protontherapy.
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Li, S., Bouchy, S., Penninckx, S., Marega, R., Fichera, O., Gallez, B., Feron, O., Martinive, P., HEUSKIN, A.-C., Michiels, C., & Lucas, S. (2019). Antibody-functionalized gold nanoparticles as tumor targeting radiosensitizers for proton therapy. Nanomedicine (London, England), 14, 317-333. https://doi.org/10.2217/nnm-2018-0161 (Original work published 2019)