Gd-EOB-DTPA enhancement pattern of hepatocellular carcinomas in rats: comparison with Tc-99m-IDA uptake

Van Beers, Bernard;Grandin, Cécile;Pauwels, Stanislas;Mottet, Isabelle;Pringot, Jacques;et.al.
(1994) Journal of Magnetic Resonance Imaging — Vol. 4, n° 3, p. 351-354 (1994)

Files

13454.pdf
  • Restricted Access
  • Adobe PDF
  • 1.88 MB
Request a copy

Details

Authors
  • Van Beers, BernardUCLouvain
    Author
  • Grandin, CécileUCLouvain
    Author
  • Pauwels, StanislasUCLouvain
    Author
  • Mottet, IsabelleUCLouvain
    Author
  • Goudemant, Jean-FrançoisUCLouvain
    Author
  • Delos, MoniqueUCLouvain
    Author
  • Demeure, RogerUCLouvain
    Author
  • Pringot, JacquesUCLouvain
    Author
Show more
Abstract
The enhancement pattern of chemically induced hepatocellular carcinomas (HCCs) after intravenous administration of the hepatobiliary magnetic resonance (MR) contrast agent gadolinium-EOB-DTPA (ethoxybenzyl-diethylenetriaminepentaacetic acid) was compared with the uptake pattern of technetium-99m-labeled iminodiacetic acid (IDA), a hepatobiliary radioactive tracer. The hepatocyte uptake of both the contrast agent and the scintigraphic agent has been shown to be driven by the organic anion transporter. The tumors enhanced less than the liver after Gd-EOB-DTPA administration, whereas the Tc-99m-IDA uptake of differentiated HCCs exceeded that of the liver at 30 minutes and 3 hours after administration. The enhancement pattern of a differentiated HCC with Gd-EOB-DTPA does not mirror that seen with Tc-99m-IDA.
Affiliations

Citations

  • APA
  • Chicago
  • FWB

Van Beers, B., Grandin, C., Pauwels, S., Mottet, I., Goudemant, J.-F., Delos, M., Demeure, R., & Pringot, J. (1994). Gd-EOB-DTPA enhancement pattern of hepatocellular carcinomas in rats: comparison with Tc-99m-IDA uptake. Journal of Magnetic Resonance Imaging, 4(3), 351-354. https://doi.org/10.1002/jmri.1880040321 (Original work published 1994)