Modulation of the action of calcium antagonists in arteries

Godfraind, Theophile;Morel, Nicole;Wibo, Maurice
(1990) Blood Vessels — Vol. 27, n° 2-5, p. 184-196 (1990)

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This paper is a review of the experimental evidence showing that specific binding sites for dihydropyridine Ca antagonists are involved in inhibition of stimulus-dependent Ca entry into arterial cells and thereby in inhibition of the contractile response. The apparent affinity of the dihydropyridine binding site is related to the proportion of a high- and a low-affinity state which is regulated by membrane potential but could also be dependent upon other factors such as G proteins. Among Ca antagonists, a subgroup of agents exhibiting voltage dependence may be identified. Their apparent pharmacological potency is highly dependent on resting membrane potential and on the duration of the depolarizing stimulus.
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Godfraind, T., Morel, N., & Wibo, M. (1990). Modulation of the action of calcium antagonists in arteries. Blood Vessels, 27(2-5), 184-196. https://doi.org/10.1159/000158809 (Original work published 1990)