Beneficial effects of a skin tolerance-tested moisturizing cream on the barrier function in experimentally-elicited irritant and allergic contact dermatitis

de Paepe, Kristien;Hachem, Jean-Pierre;Vanpee, Els;Goossens, An;Rogiers, Vera;et.al.
(2001) Contact Dermatitis : environmental and occupational dermatitis — Vol. 44, n° 6, p. 337-343 (2001)

Files

42697.pdf
  • Restricted Access
  • Adobe PDF
  • 2.9 MB
Request a copy

Details

Authors
  • de Paepe, KristienVrije Universiteit Brussel
    Author
  • Hachem, Jean-PierreVUB
    Author
  • Vanpee, ElsVUB
    Author
  • Goossens, AnVrije Universiteit Brussel
    Author
  • Lachapelle, Jean-MarieUCLouvain
    Author
  • Rogiers, VeraVrije Universiteit Brussel
    Author
Show more
Abstract
In experimentally-induced irritant (ICD) and allergic (ACD) contact dermatitis, an oil-in-water (o/w) cream was applied to investigate its effects on a disturbed barrier function compared to untreated physiological barrier repair. Transepidermal water loss (TEWL) measurements were performed. Before the start of the experiments, the skin tolerance of the cream was examined, revealing the non-irritating characteristics of the ingredients and the absence of any contact allergic patch test reaction. In the ICD study, sodium lauryl sulfate (SLS) patches were applied to the forearms of young female volunteers. Consequently, it was observed that repeated cream application (14 days, 2x/day) significantly improved the TEWL of SLS-damaged skin, leading to a complete recovery on day 15. In the ACD study, disruption of skin barrier function was obtained by a nickel-mediated contact allergy patch (CAP:) test. The cream was then applied 2x/day for 4 consecutive days. Assessment of TEWL clearly showed that recovery of the disrupted skin significantly improved after cream application in comparison to untreated barrier repair.
Affiliations

Citations

  • APA
  • Chicago
  • FWB

de Paepe, K., Hachem, J.-P., Vanpee, E., Goossens, A., Germaux, M.-A., Lachapelle, J.-M., Lambert, J., Matthieu, L., Roseeuw, D., Suys, E., Van Hecke, E., & Rogiers, V. (2001). Beneficial effects of a skin tolerance-tested moisturizing cream on the barrier function in experimentally-elicited irritant and allergic contact dermatitis. Contact Dermatitis : environmental and occupational dermatitis, 44(6), 337-343. https://doi.org/10.1034/j.1600-0536.2001.044006337.x (Original work published 2001)