L’atrophie musculaire induite par les glucocorticoïdes : présentation clinique, mécanismes physiopathologiques et implications thérapeutiques
(2019) Louvain médical — Vol. 138, n° 7, p. 411-416 (2019)
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- Authors
Thissen, Jean-Paul 
- Abstract
- (en) [Glucocorticoid-induced muscle atrophy: clinical presentation, physiopathological mechanisms, and therapeutic implications] Glucocorticoids (GC) are used in all medical areas because of their antiinflammatory and immunosuppressive effects. Their undesirable effects are, however, much feared, in particular cortisone-induced myopathy (CD). This condition is characterized by insidious muscle atrophy, exhibiting an important prognostic role. CD is related to the GC-induced imbalance between muscle protein synthesis and degradation, promoting their degradation yet inhibiting their synthesis. We have herein undertaken a review focused on CD’s main pathophysiological mechanisms, along with a discussion on potential targets, such as myostatin, activin receptor Type IIB, TRAF6, and REDD1. To end with, practical recommendations for the fight against CD have been developed, including resistance exercises.
- Affiliations
Citations
Montigny, P., Thissen, J.-P., Lauwerys, B., & Houssiau, F. (2019). L’atrophie musculaire induite par les glucocorticoïdes : présentation clinique, mécanismes physiopathologiques et implications thérapeutiques. Louvain médical, 138(7), 411-416. https://hdl.handle.net/2078.5/95556 (Original work published 2019)