Cystathionine β-synthase genetic variant rs2124459 is associated with a reduced risk of cleft palate in French and Belgian populations.

Goffinet, Laetitia;Oussalah, Abderrahim;Guéant-Rodriguez, Rosa-Maria;Chery, Céline;Guéant, Jean-Louis;et.al.
(2016) Journal of Medical Genetics : an international peer-reviewed journal for health professionals and researchers in all areas of genetics — Vol. 53, n° 12, p. 828-834 (2016)

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Authors
  • Goffinet, Laetitia
    Author
  • Oussalah, Abderrahim
    Author
  • Guéant-Rodriguez, Rosa-Maria
    Author
  • Chery, Céline
    Author
  • Vikkula, MiikkaUCLouvain
    Author
  • Guéant, Jean-Louis
    Author
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Abstract
Orofacial cleft (OFC) is the most prevalent craniofacial birth defect. Genes involved in one-carbon, folate and vitamin B12 metabolisms have been associated with OFC but no study performed a concomitant assessment on genes involved in these three pathways.
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Goffinet, L., Oussalah, A., Guéant-Rodriguez, R.-M., Chery, C., Basha, M., Avogbe, P. H., Josse, T., Jeannesson, E., Rouyer, P., Flayac, J., Gerard, P., Le Touze, A., Bonin-Goga, B., Goga, D., Simon, E., Feillet, F., Vikkula, M., & Guéant, J.-L. (2016). Cystathionine β-synthase genetic variant rs2124459 is associated with a reduced risk of cleft palate in French and Belgian populations. Journal of Medical Genetics : an international peer-reviewed journal for health professionals and researchers in all areas of genetics, 53(12), 828-834. https://doi.org/10.1136/jmedgenet-2016-104111 (Original work published 2016)