D-penicillamine Induced Crescentic Glomerulonephritis - Report and Review of the Literature
(1987) Journal of Rheumatology — Vol. 14, n° 5, p. 1036-1041 (1987)
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- Abstract
- (en) A 56-year-old woman with scleroderma developed rapidly progressive glomerulonephritis with epithelial crescents associated with hemoptysis after 27 months of D-penicillamine therapy and a cumulative dose of 1,200 g. Renal failure necessitated 5 hemodialysis sessions. D-penicillamine was withdrawn and glucocorticoids combined with azathioprine were given with good recovery of renal function. The 9 other reported cases of D-penicillamine induced rapidly progressive glomerulonephritis have been reviewed. This syndrome is potentially life-threatening: the 5 untreated patients died, whereas 5 patients given immunosuppressive therapy are alive.
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Citations
Devogelaer, J.-P., Pirson, Y., Vandenbroucke, J.-M., Cosyns, J.-P., Brichard, S., & Nagant De Deuxchaisnes, C. (1987). D-penicillamine Induced Crescentic Glomerulonephritis - Report and Review of the Literature. Journal of Rheumatology, 14(5), 1036-1041. https://hdl.handle.net/2078.5/71216 (Original work published 1987)