Microporenic Acids A–G, Biofilm Inhibitors, and Antimicrobial Agents from the Basidiomycete Microporus Species
(2018) Journal of Natural Products — Vol. 2018, p. 1-7 (2018)
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- Abstract
- The need for effective compounds to combat antimicrobial resistance and biofilms which play important roles in human infections continues to pose a major health challenge. Seven previously undescribed acyclic diterpenes linked to isocitric acid by an ether linkage, microporenic acids A-G (1-7), were isolated from the cultures of a hitherto undescribed species of the genus Microporus (Polyporales, Basidiomycota) originating from Kenya's Kakamega forest. Microporenic acids D and E (4 and 5) showed antimicrobial activity against a panel of Gram positive bacteria and a yeast, Candida tenuis. Moreover, microporenic acids A and B (1 and 2) demonstrated dose-dependent inhibition of biofilm formation by Staphylococcus aureus. Compound 1 further showed significant activity against Candida albicans and Staphylococcus aureus preformed biofilms.
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Citations
Chepkirui, C., Yuyama, K. T., Wanga, L. A., Decock, C., Matasyoh, J. C., Abraham, W.-R., & Stadler, M. (2018). Microporenic Acids A–G, Biofilm Inhibitors, and Antimicrobial Agents from the Basidiomycete Microporus Species. Journal of Natural Products, 2018, 1-7. https://doi.org/10.1021/acs.jnatprod.7b00764 (Original work published 2018)