Catalyse de réactions conjuguées par les complexes de cuivre (I) : méthodologies et applications
(2012)
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- Authors
- Supervisors
- Riant, Olivier
- Abstract
- (en) During this work, we studied the catalytic activity of air stable copper (I) fluoride complexes. These were used in different reactions, mainly in adding nucleophile onto a variety of electrophiles. We synthesized silylated allenes with very good diastereomeric ration (> 95/5) by adding a silylated derivative on enynes wich contain an asymmetric propargyl alcohol. A new air stable and ready to use copper catalyst was also prepared during this work. Addition of nucleophilic species such as alkyl, hydrides or silyl on electrophiles (aldehydes, ketones and enynes) by this new generation of asymmetric catalysts has been evaluated successfully. Good enantiomeric selectivities are obtained The methodology of the laboratory was finally applied to the preparation of a synthetic intermediate of Marrubiine.
- Affiliations
Citations
Hermant, T. (2012). Catalyse de réactions conjuguées par les complexes de cuivre (I) : méthodologies et applications. https://hdl.handle.net/2078.5/156467