Exploration of nociceptive cortical processing with steady-state evoked potentials
(2011) The 7th Congress of the European Federation of IASP Chapters (EFIC) — Location: Hamburg, Deutschland
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- The periodic presentation of a sensory stimulus induces, at certain frequencies of stimulation, a sustained electroencephalographic response known as steady-state evoked potentials (SS-EP). SS-EPs are considered to reflect entrainment of cortical sensory networks resonating at the frequency of stimulation. In the present study we characterize and compare SS-EPs elicited by the selective electrical activation of nociceptive Aδ-fibers and non-nociceptive Aβ-fibers. Nine subjects took part in the experiment. Ten second trains of nociceptive (intra-epidermal electrical stimulation) and non-nociceptive (transcutaneous electrical stimulation) stimuli were applied to the left and right hand in separate blocks. Trains consisted of 0.5 ms constant-current pulses modulated at 3, 7, 13, 23 and 43 Hz. Consistent nociceptive and non-nociceptive SS-EPs were recorded at all stimulation frequencies. Whereas non-nociceptive SS-EPs were maximal over the parietal region contralateral to the stimulated side, nociceptive SS-EPs were maximal at the vertex and symmetrically distributed over both hemispheres, thus indicating that the two responses reflect the entrainment of distinct neuronal populations. The recording of nociceptive and non-nociceptive somatosensory SS-EPs offers a unique opportunity to study the cortical representation of nociception and touch in humans.
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Colon, E., Nozaradan, S., Legrain, V., & Mouraux, A. (2011). Exploration of nociceptive cortical processing with steady-state evoked potentials. The 7th Congress of the European Federation of IASP Chapters (EFIC), Hamburg, Deutschland. https://hdl.handle.net/2078.5/194831