Immunité sécrétoire des voies respiratoires.
(2003) Revue des Maladies Respiratoires — Vol. 20, n° 6 Pt 1, p. 928-939 (2003)
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- [Secretory Immunity of the Airways] INTRODUCTION: Continuous exposure of the respiratory tract to inhaled particles and microbes implies the presence of effective defence mechanisms at a bronchial and alveolar level. STATE OF ART: Among the mechanisms involved secretory mucosal immunity contributes considerably to the defence of the bronchial tree. This immunity depends essentially on the active trans-epithelial transport of IgA involved in both innate non-specific and acquired specific immunity. Recently an IgA receptor has been identified on the surface of phagocytes including alveolar macrophages, establishing a link between alveolar and bronchial defences. PERSPECTIVES: The respiratory mucosa represents a crucial interface between the host and its environment, and should provide in the future a new target for the development of diagnostic and therapeutic tools. CONCLUSIONS: Beyond its function as an anatomical barrier the bronchial epithelium possesses a secretory activity that is essential for the protection of the lung. Despite a better understanding of mucosal immunity this secretory activity and in particular the part played by IgA remains to be elucidated.
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Maury, G., Pilette, C., & Sibille, Y. (2003). Immunité sécrétoire des voies respiratoires. Revue des Maladies Respiratoires, 20(6 Pt 1), 928-939. https://hdl.handle.net/2078.5/96227 (Original work published 2003)