Hypothermia and Meconium Aspiration Syndrome: International Multicenter Retrospective Cohort Study.
(2016) American Journal of Respiratory and Critical Care Medicine — Vol. 194, n° 3, p. 381-384 (2016)
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- Abstract
- (en) To the Editor: Whole-body hypothermia (WBH) is the cornerstone treatment of neonatal hypoxic-ischemic encephalopathy (HIE) resulting from perinatal asphyxia (1). HIE might occur with meconium aspiration syndrome (MAS), which is characterized by surfactant dysfunction and lung inflammation (2). Animal and translational studies suggest that “lung cooling” could have beneficial effects, reducing lung inflammation and improving surfactant function (3, 4). Recent case reports of an infant and an adult patient with acute respiratory distress syndrome also showed gas exchange improvement during WBH (5, 6). Theoretically, WBH could clinically improve MAS through its effect on lung inflammation and surfactant activity. We performed a retrospective cohort study hypothesizing that WBH improves gas exchange and clinical outcomes in MAS, especially in the severest cases. Eleven tertiary academic neonatal or pediatric intensive care units (ICUs) in the European Union, United States, Brazil, and Australia participated. All centers had known expertise in neonatal ventilation for severe MAS and established electronic databases [...]
- Affiliations
University of California, San Francisco Department of Pediatrics
Citations
De Luca, D., Tingay, D. G., van Kaam, A., Brunow de Carvalho, W., Valverde, E., Christoph Roehr, C., Mosca, F., Matassa, P. G., Danhaive, O., Carnielli, V. P., & Piastra, M. (2016). Hypothermia and Meconium Aspiration Syndrome: International Multicenter Retrospective Cohort Study. American Journal of Respiratory and Critical Care Medicine, 194(3), 381-384. https://doi.org/10.1164/rccm.201602-0422LE (Original work published 2016)