An organic solvent free process for the demethylation of 4-(4-methoxyphenyl)butanoic acid
(2006) Green Chemistry — Vol. 8, n° 2, p. 181-182 (2006)
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- Abstract
- A mild and efficient organic solvent free process has been developed for the synthesis of 4-(4-hydroxyphenyl)butanoic acid, a key intermediate in the synthesis of LY518674. Thus we have achieved the demethylation of 4-(4-methoxyphenyl)butanoic acid with only a slight excess of aqueous HBr and without phase transfer catalysis. In addition, 4-(4-hydroxyphenyl)butanoic acid is easily obtained by direct crystallization from the reaction mixture.
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Delhaye, L., Diker, K., Donck, T., & Merschaert, A. (2006). An organic solvent free process for the demethylation of 4-(4-methoxyphenyl)butanoic acid. Green Chemistry, 8(2), 181-182. https://doi.org/10.1039/b512176k (Original work published 2006)