You are what you eat: modulating metabolism to direct stem cell fate
(2021) 6th TERMIS World Congress — Location: Maastricht, The Netherlands (15.November.2021)
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- Abstract
- Unraveling the molecular regulation of stem cells is critical to understand the functioning of these cells in health and disease, and to leverage their potential for regenerative medicine. Once thought to be a mere consequence of the state of a cell, intermediary metabolism is now known to play a key role in dictating whether a stem cell proliferates, differentiates or remains quiescent. In this presentation, I will highlight the recent methodological advances that allow us to investigate stem cell metabolism. I will further discuss our findings on the role of cellular metabolism in skeletal stem cells during bone fracture healing, and the potential of targeting metabolic pathways in bone tissue engineering approaches.
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Citations
van Gastel, N. (2021). You are what you eat: modulating metabolism to direct stem cell fate. 6th TERMIS World Congress, Maastricht, The Netherlands. https://hdl.handle.net/2078.5/109458