Immunosuppressive low-density neutrophils in the blood of cancer patients display a mature phenotype

Vanhaver, Christophe;Aboubakar Nana, Frank;Delhez, Nicolas;Luyckx, Mathieu;Bruger, Annika;et.al.
(2023) Life Science Alliance — Vol. 7, n° 1, p. e202302332 [1-14] (2023)

Files

immunosuppressive-low-density-neutrophils-in-the-blood-of-cancer-patients-display-a-mature-phenotype.pdf
  • Open Access
  • Adobe PDF
  • 3.04 MB
Download

Details

Authors
Show more
Abstract
The presence of human neutrophils in the tumor microenvironment is strongly correlated to poor overall survival. Most previous studies have focused on the immunosuppressive capacities of low-density neutrophils (LDN), also referred to as granulocytic myeloid-derived suppressor cells, which are elevated in number in the blood of many cancer patients. We observed two types of LDN in the blood of lung cancer and ovarian carcinoma patients: CD45high LDN, which suppressed T-cell proliferation and displayed mature morphology, and CD45low LDN, which were immature and non-suppressive. We simultaneously evaluated the classical normal-density neutrophils (NDN) and, when available, tumor-associated neutrophils. We observed that NDN from cancer patients suppressed T-cell proliferation, and NDN from healthy donors did not, despite few transcriptomic differences. Hence, the immunosuppression mediated by neutrophils in the blood of cancer patients is not dependent on the cells’ density but rather on their maturity.
Affiliations

Citations

  • APA
  • Chicago
  • FWB

Vanhaver, C., Aboubakar Nana, F., Delhez, N., Luyckx, M., Hirsch, T., Bayard, A., Houbion, C., Dauguet, N., Brochier, A., van der Bruggen, P., & Bruger, A. (2023). Immunosuppressive low-density neutrophils in the blood of cancer patients display a mature phenotype. Life Science Alliance, 7(1), e202302332 [1-14]. https://doi.org/10.26508/lsa.202302332 (Original work published 2023)