The genetic signature of acute leukemia in infacy

Chantrain, Christophe;Poirel, Hélène
(2010) Hem-Onc — Vol. 1, n° 1, p. 1-8 (2010)

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  • Chantrain, ChristopheUCLouvain
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  • Poirel, HélèneUCLouvain
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Abstract
Infant leukemia is a rare malignant disease with clinical and biological features distinct from older children. It is characterized by a high incidence of mixed lineage leukemia (MLL) gene rearrangement and a poor outcome despite intensive chemotherapy. Recent genetic studies argue in favor of a unique biology of infant acute leukemia. This review describes the specific genetic signature of infant leukemia. It discusses the important insights it provides into the understanding of leukemogenesis and reviews the influence of genetics on the prognosis and the treatment of leukemia during infancy
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Chantrain, C., & Poirel, H. (2010). The genetic signature of acute leukemia in infacy. Hem-Onc, 1(1), 1-8. https://hdl.handle.net/2078.5/153724 (Original work published 2010)