Atrial fibrillation (AF) patients treated according to a rate-control strategy seem to have excellent outcomes as long as their ventricular response is kept low. However, the stringency of the rate control to adopt with pharmacologic agents is not clearly defined. In particular, the clinical importance of preserving a heart rate (HR) reserve (HRR) during exercise has not yet been investigated.
De Schryver, N., Scavée, C., Marchandise, S., Pasquet, A., de Meester de Ravenstein, C., & Le Polain De Waroux, J.-B. (2014). Predictive value of the heart rate reserve in patients with permanent atrial fibrillation treated according to a strict rate-control strategy. Europace, 16(8), 1125-1130. https://doi.org/10.1093/europace/euu033 (Original work published 2014)