Medetomidine Ketamine Anesthesia in Cats

Verstegen, J.;Fargetton, X.;Ectors, F.
(1989) Acta Veterinaria Scandinavica (Print) — p. 117-123 (1989)

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  • Verstegen, J.
    Author
  • Fargetton, X.
    Author
  • Ectors, F.
    Author
Abstract
The medetomidine/ketamine combination was evaluated as an anaesthetic in cats undergoing ovariectomy. It was compared with acepromazine/ketamine, xylazine/ketamine and zolazepam/tiletamine combinations. 60 animals, divided into 6 groups of 10 animals were involved. Medetomidine highly potentiated the anaesthetic effects of ketamine and balanced the two main disadvantages of this drug: weak muscle relaxation and poor analgesia in deep organs. 80 micrograms medetomidine/kg--5 mg ketamine/kg provided a duration of anaesthesia longer than 1 mg acepromazine/kg--10 mg ketamine/kg, and not significantly different from those induced by 1 mg xylazine/kg--10 mg ketamine/kg or 7.5 mg zolazepam/kg--7.5 mg tiletamine/kg. Furthermore, it produced a better muscle relaxation than acepromazine/ketamine and zolazepam/tiletamine combinations. The analgesia in deep organs observed after medetomidine/ketamine administration appeared to be more substantial than that observed after acepromazine/ketamine or xylazine/ketamine combinations. The stimulating effect on heart rate of ketamine compensated the bradycardiac effect of medetomidine. Nevertheless, the administration of 80 micrograms medetomidine/kg--5 mg ketamine/kg resulted as with xylazine/ketamine, in decreasing heart rate whereas acepromazine/ketamine and zolazepam/tiletamine combinations did not exhibit bradycardiac effect. It was concluded that the medetomidine/ketamine combination provided a suitable anaesthesia for cats characterized by rapid induction, good muscle relaxation, good analgesia and bradycardia.
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Verstegen, J., Fargetton, X., & Ectors, F. (1989). Medetomidine Ketamine Anesthesia in Cats. Acta Veterinaria Scandinavica (Print), 117-123. https://hdl.handle.net/2078.5/64643 (Original work published 1989)