Administration transdermique de médicaments par electroporation
(1999) Academie Royale de Medecine de Belgique. Bulletin et Memoires — Vol. 154, n° 6 Pt 2, p. 327-333 (1999)
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- Abstract
- (en) Short high-voltage pulses have been shown to increase, accelerate and broaden transdermal drug delivery to molecules of variable physicochemical properties, i.e., from 18 to 38,000 Da, hydro- and lipophilic, neutral and charged molecules, via a mechanism hypothesized to involve electroporation of the stratum corneum lipid bilayers. Transport is increased by up to 4 orders of magnitude, and onset times for significant transport reduce from hours by passive diffusion to a few minutes.
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Vanbever, R. (1999). Administration transdermique de médicaments par electroporation. Academie Royale de Medecine de Belgique. Bulletin et Memoires, 154(6 Pt 2), 327-333. https://hdl.handle.net/2078.5/240651 (Original work published 1999)