A new flavone sulfonic acid from Phyllanthus urinaria

Thanh, Nguyen Van;Huong, Phan Thi Thanh;Nam, Nguyen Hoai;Cuong, Nguyen Xuan;Minh, Chau Van;et.al.
(2014) Phytochemistry Letters — Vol. 7, n° 1, p. 182-185 (2014)

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Authors
  • Thanh, Nguyen VanInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Cau Giay, Hanoi, Viet Nam
    Author
  • Huong, Phan Thi ThanhInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Cau Giay, Hanoi, Viet Nam
    Author
  • Nam, Nguyen HoaiInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Cau Giay, Hanoi, Viet Nam
    Author
  • Cuong, Nguyen XuanInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Cau Giay, Hanoi, Viet Nam
    Author
  • Gordien, AndreaUCLouvain
    Author
  • Quetin-Leclercq, JoëlleUCLouvain
    Author
  • Minh, Chau VanInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Cau Giay, Hanoi, Viet Nam
    Author
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Abstract
One new flavone derivative, urinariaflavone (1), and eight known compounds (2–9) were isolated from the methanolic extract of Phyllanthus urinaria L. leaves. Their structures were established by MS, 1D and 2D NMR experiments, and comparison with literature data. All isolated compounds were tested for their cytotoxic activity against CHO (Chinese hamster ovary) and J774 (Murine macrophage) cell lines. Cytotoxic effects (IC50s ∼ 6.00–41.30 μM) on both cell lines were observed for compounds 4, 5, and 7.
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Thanh, N. V., Huong, P. T. T., Nam, N. H., Cuong, N. X., Thao, N. P., Dejaegher, B., Gordien, A., Vander Heyden, Y., Quetin-Leclercq, J., & Minh, C. V. (2014). A new flavone sulfonic acid from Phyllanthus urinaria. Phytochemistry Letters, 7(1), 182-185. https://doi.org/10.1016/j.phytol.2013.11.013 (Original work published 2014)