Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus.
(2009) Annals of the Rheumatic Diseases — Vol. 68, n° 3, p. 412-415 (2009)
Files
27547.pdf
Restricted Access - Adobe PDF
- 2.3 MB
Details
- Authors
- Abstract
- OBJECTIVE: To investigate differences in clinical signs and symptoms, and in antinuclear antibodies (ANA), between patients with juvenile-onset and adult-onset systemic lupus erythematosus (SLE). METHODS: Clinical and serological data of 56 patients with juvenile-onset SLE were compared with data of 194 patients with adult-onset SLE. ANA were determined by line immunoassay and by indirect immunofluorescence on Crithidia luciliae. RESULTS: Renal involvement, encephalopathy and haemolytic anaemia were seen, and anti-dsDNA, anti-ribosomal P and antihistone antibodies found, significantly more often in juvenile-onset SLE. Anti-dsDNA antibodies were directly associated, and anti-ribosomal P antibodies inversely associated, with renal involvement in juvenile-onset SLE. In juvenile patients with SLE and anti-dsDNA and without anti-ribosomal P antibodies the odds ratio for glomerulonephritis was 9.00; no patients with anti-ribosomal P but without anti-dsDNA had renal involvement. CONCLUSION: Patients with juvenile-onset SLE more often have renal involvement and encephalopathy than patients with adult-onset SLE. Anti-ribosomal P, anti-dsDNA and antihistone antibodies are more often found in patients with juvenile-onset SLE.
- Affiliations
Citations
Hoffman, I. E. A., Lauwerys, B., De Keyser, F., Huizinga, T. W. J., Isenberg, D., Cebecauer, L., Dehoorne, J., Joos, R., Hendrickx, G., Houssiau, F., & Elewaut, D. (2009). Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus. Annals of the Rheumatic Diseases, 68(3), 412-415. https://doi.org/10.1136/ard.2008.094813 (Original work published 2009)