Myeloperoxidase and its products in synovial fluid of patients with treated or untreated rheumatoid arthritis
(2014) Free Radical Research — Vol. 48, n° 4, p. 461-465 (2014)
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- OBJECTIVE: Plasma and synovial myeloperoxidase (MPO) and its products were strongly associated with osteoarthritis (OA) and rheumatoid arthritis (RA). In addition, it is well known that there is a link between oxidative stress and cytokines. The present study aims at investigating the link between synovial MPO (and its products), interleukin (IL)-18, which is involved in the degradation of articular cartilage in RA, and IL-8, which is involved in recruitment and activation of neutrophils during inflammation. Effects of the treatment of RA on the biological parameters were also investigated. METHODS: Patients (n = 105) were studied including 39 patients with OA, 33 with RA and 33 with RA receiving a specific treatment. Disease activity score (DAS-28) was calculated whereas MPO antigen/activity, neutrophils, chloro-tyrosine (Cl-Tyr), homocitrulline (Hcit), IL-8, and IL-18 were measured in synovial fluid (SF) and CRP was measured in serum. RESULTS: DAS-28 and CRP levels were not significantly different between groups. MPO activity, and MPO, Cl-Tyr, and Hcit levels were significantly higher in SF of RA patients than OA patients. MPO specific activity (MPO activity/antigen ratio) was significantly lower in treated than in untreated RA patients as was IL-8. MPO activity and concentration were correlated with IL-8 and IL-18 in untreated but not in treated RA patients. CONCLUSIONS: MPO level is related to IL-8 and IL-18 levels in untreated RA patients. A link has been shown between treatment and decrease of IL-8, MPO specific activity and Hcit in SF. The causal role of MPO in SF inflammation and how treatment can affect MPO specific activity need further investigations.
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Nzeusseu Toukap, A., Delporte, C., Noyon, C., Franck, T., Rousseau, A., Serteyn, D., Raes, M., Vanhaeverbeek, M., Moguilevsky, N., Nève, J., Vanhamme, L., Durez, P., Van Antwerpen, P., & Zouaoui Boudjeltia, K. (2014). Myeloperoxidase and its products in synovial fluid of patients with treated or untreated rheumatoid arthritis. Free Radical Research, 48(4), 461-465. https://doi.org/10.3109/10715762.2014.886327 (Original work published 2014)