Acute cholestatic hepatitis with rash and hypereosinophilia associated with ranitidine treatment.
(1993) Acta Clinica Belgica (Multilingual Edition) — Vol. 48, n° 2, p. 109-114 (1993)
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- Abstract
- We report a case of acute cholestatic hepatitis associated with rash and hypereosinophilia, in which the absence of transfusion, intercurrent viral infection, alcohol consumption or other hepatotoxic drugs are suggestive of ranitidine-induced hepatotoxicity. The pathogenesis of the disorder is unknown, but the lack of a dose-effect relationship, the rarity and unpredictability of the reaction, as well as the clinical signs suggest that hypersensitivity is involved. Physicians should be aware of this rare and idiosyncratic side-effect of ranitidine.
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Devuyst, O., Lefebvre, C., Geubel, A., & Coche, E. (1993). Acute cholestatic hepatitis with rash and hypereosinophilia associated with ranitidine treatment. Acta Clinica Belgica (Multilingual Edition), 48(2), 109-114. https://hdl.handle.net/2078.5/52939 (Original work published 1993)