Cdna Cloning, Characterization, and Brain Region Specific Expression of a Neuromedin-b Preferring Bombesin Receptor
(1991) Neuron — Vol. 6, n° 3, p. 421-430 (1991)
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- Recent binding studies in the central nervous system and other tissues provide evidence that the mammalian bombesin-like peptides, gastrin-releasing peptide (GRP) and neuromedin-B (NMB), exert their numerous physiological effects through at least two different receptors. We describe the structure and expression of a cloned NMB-preferring bombesin receptor (NMB-R) with properties distinct from a GRP-preferring bombesin receptor (GRP-R) reported previously. In particular, the NMB-R shows higher affinity binding to NMB than to GRP in BALB 3T3 fibroblasts expressing the cloned NMB-R. The distinct regional distribution of NMB-R and GRP-R mRNA in the brain suggests that both bombesin receptor subtypes play independent roles in mediating many of the dramatic effects of bombesin-like peptides in the central nervous system.
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Wada, E., Way, J., Shapira, H., Kusano, K., Lebacqverheyden, AM., Coy, D., Jensen, R., & Battey, J. (1991). Cdna Cloning, Characterization, and Brain Region Specific Expression of a Neuromedin-b Preferring Bombesin Receptor. Neuron, 6(3), 421-430. https://doi.org/10.1016/0896-6273(91)90250-4 (Original work published 1991)