Lack of association between the nasopharyngeal carriage of Streptococcus pneumoniae and Staphylococcus aureus in HIV-1-infected South African children

McNally, Lisa M.;Jeena, Prakash M.;Gajee, Kavitha;Sturm, A. Willem;Goldblatt, David;et.al.
(2006) 4th International Symposium on Pneumococci and Pneumococcal Diseases — Location: Helsinki(Finland) (9.May.2004)

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  • McNally, Lisa M.
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  • Jeena, Prakash M.
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  • Gajee, Kavitha
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  • Sturm, A. Willem
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  • Goldblatt, David
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Abstract
We investigated the nasopharyngeal carriage of Streptococcus pneumoniae and Staphylococcus aureus in 355 children hospitalized with severe pneumonia. Of the children, 239 (67.3%) were human immunodeficiency virus (HIV)-1 positive; 169 (47.6%) carried S. pneumoniae, 91 (25.6%) carried S. aureus, and 33 (9.3%) carried both. S. pneumoniae carriage was not related to HIV-1 status. The HIV-1-positive children had a significantly higher rate of S. aureus carriage than did the HIV-1-negative children (31.4% vs. 13.8%; P <.001). The rate of S. aureus carriage in the HIV-1-negative S. pneumoniae carriers was significantly lower than that in the noncarriers (5.5% vs. 21.3%; P=.013), but the rate of S. aureus carriage in the HIV-1-positive S. pneumoniae carriers was not significantly lower than that in the noncarriers (26.3% vs. 36.0%;). We did not find a negative association between S. pneumoniae and S. aureus carriage in HIV-1-positive hospitalized children with severe pneumonia.
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McNally, L. M., Jeena, P. M., Gajee, K., Sturm, A. W., Tomkins, A. M., Coovadia, H. M., & Goldblatt, D. (2006). Lack of association between the nasopharyngeal carriage of Streptococcus pneumoniae and Staphylococcus aureus in HIV-1-infected South African children. The Journal of Infectious Diseases, 194(3), 385-390. https://doi.org/10.1086/505076 (Original work published 2006)