(en) To the Editor: Idiopathic pulmonary fibrosis (IPF) lungs display aberrant epithelial structures, namely honeycomb cysts (HC), lined by a bronchiolized epithelium and filled with mucus-like secretions, and hyperplasic type 2 alveolar epithelial cell cysts. The recent discovery of pathological bronchial epithelial cell subpopulations in IPF, together with mucosal immunity modifications, further questions the role of these structures. [...]
Plante-Bordeneuve, T., Bertrand, Y., Lecocq, M., Hoton, D., Fillee, C., Lacroix, V., Rondelet, B., Wuyts, W., Bouzin, C., Pilette, C., & Froidure, A. (2024). The IgA-pIgR System Is Dysregulated in Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine, 210(6), 841-844. https://doi.org/10.1164/rccm.202401-0043LE (Original work published 2024)