Isolation and identification by FAB mass spectrometry and NMR spectroscopy of a demethylated metabolite of FK506 from erythromycin-induced rabbit liver microsomes.
(1993) Pharmaceutica Acta Helvetiae — Vol. 68, n° 1, p. 35-41 (1993)
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- Abstract
- A new demethylated metabolite, extracted from erythromycin-induced rabbit liver microsomes incubation media, isolated by HPLC and identified by FAB/MS and NMR, is described. Moreover, NMR spectra suggest the existence of tautomeric forms of this O-demethylated metabolite of FK506.
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Lhoëst, G., Maton, N., & Verbeeck, R.-K. (1993). Isolation and identification by FAB mass spectrometry and NMR spectroscopy of a demethylated metabolite of FK506 from erythromycin-induced rabbit liver microsomes. Pharmaceutica Acta Helvetiae, 68(1), 35-41. https://doi.org/10.1016/0031-6865(93)90006-R (Original work published 1993)