A case of cholestatic hepatitis associated with D-penicillamine therapy for rheumatoid arthritis.
(1985) International Journal of Clinical Pharmacology Research — Vol. 5, n° 1, p. 35-38 (1985)
Files
No attached file found for this publication.
Details
- Authors
- Abstract
- A male aged 72 years suffering from erosive seropositive rheumatoid arthritis developed jaundice after one month on D-penicillamine after a cumulative dose of 5.625 g. The biological abnormalities were characteristic of cholestasis. There were no gall-stones. The liver biopsy showed severe intrahepatocellular cholestasis with a slight degree of cellular cholangitis and with eosinophils in the portal tracts. There was no sign of cellular necrosis. After cessation of D-penicillamine, the jaundice cleared within three weeks and the enzymes were normalized within two months. The aetiology is discussed and the cases of the literature are reviewed. This case represents a further instance of D-penicillamine-induced cholestatic hepatitis.
- Affiliations
Citations
Devogelaer, J.-P., Huaux, J. P., Coche, E., Rahier, J., & Nagant de Deuxchaisnes, C. (1985). A case of cholestatic hepatitis associated with D-penicillamine therapy for rheumatoid arthritis. International Journal of Clinical Pharmacology Research, 5(1), 35-38. https://hdl.handle.net/2078.5/128452 (Original work published 1985)