A single nucleotide polymorphism in the DNA polymerase gamma gene of Saccharomyces cerevisiae laboratory strains is responsible for increased mitochondrial DNA mutability

Baruffini, Enrico;Lodi, Tiziana;Dallabona, Cristina;Foury, Françoise
(2007) Genetics : a periodical record of investigations bearing on heredity and variation — Vol. 177, n° 2, p. 1227-1231 (2007)

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Authors
  • Baruffini, Enrico
    Author
  • Lodi, Tiziana
    Author
  • Dallabona, Cristina
    Author
  • Foury, FrançoiseUCLouvain
    Author
Abstract
In the Saccharomyces cerevisiae strains used for genome sequencing and functional analysis, the mitochondrial DNA replicase Mip1p contains a single nucleotide polymorphism changing the strictly conserved threonine 661 to alanine. This substitution is responsible for the increased rate of mitochondrial DNA point mutations and deletions in these strains.
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Baruffini, E., Lodi, T., Dallabona, C., & Foury, F. (2007). A single nucleotide polymorphism in the DNA polymerase gamma gene of Saccharomyces cerevisiae laboratory strains is responsible for increased mitochondrial DNA mutability. Genetics : a periodical record of investigations bearing on heredity and variation, 177(2), 1227-1231. https://doi.org/10.1534/genetics.107.079293 (Original work published 2007)