Suloctidil increases the rat brain cortex microvascular regeneration after a lesion.
(1989) Life Sciences — Vol. 44, n° 1, p. 41-47 (1989)
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- Abstract
- A "cavity" lesion made by aspiration in the rat occipital cortex induces a parenchymal and a vascular reaction in its vicinity. The first was mainly characterized by cellular necrosis and gliosis, the second by an increase of the vascular network. In vehicle treated rats, a 50% significant increase of the vascular network was observed around the cavity 4 days after the lesion, in comparison to the uninjured contralateral cortex. The effects of a vasoactive substance, suloctidil, on the vascular reaction was studied in the brain cortex. A single oral dose of suloctidil (30 mg/kg; 2 hours before the sacrifice) gave the same effect as the vehicle group. After 8 days of suloctidil oral administration (30 mg/kg; twice daily: 4 days before lesion and 4 days after) a significant increase (123%) of the vascular network was observed around the cavity. The hypothetical ways by which a chronic treatment of suloctidil induces this increase of the neovascularization observed after cortical lesion are discussed.
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De Paermentier, F., Heuschling, P., Knoops, B., Janssens De Varebeke, P., Pauwels, G., Laszlo De Kaszon-Jakabfalva, C., & Van den Bosch De Aguilar, P. (1989). Suloctidil increases the rat brain cortex microvascular regeneration after a lesion. Life Sciences, 44(1), 41-47. https://hdl.handle.net/2078.5/80449 (Original work published 1989)