Additional value of single nucleotide polymorphisms (SNPs) testing on an existing clinical risk calculator in prostate cancer patients
(2016)
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- Abstract
- The objective of the thesis was to investigate the added value of Single Nucleotide Polymorphisms (SNPs) to a validated clinical risk calculator for the prediction of prostate cancer risk in screened patients. After a review of the current knowledge on prostate cancer screening and the studied applications of SNP genotyping in this process, we present the results of our own clinical study in patients screened for prostate cancer, in whom 9 SNPs were genotyped and integrated in a clinical model. The performance of the clinico-genetic model thus built was compared to that of the clinical model alone, to evaluate the improvement in prediction brought by the genetic information. The thesis also includes an original methodological study, aimed to develop a multiplex pyrosequencing method, for simultaneous analysis of 4 or 5 SNPs in a single experiment. We end by presenting the perspectives of our research and commenting on how SNP genotyping could assist clinicians in day-to-day practice.
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Citations
Butoescu, V. (2016). Additional value of single nucleotide polymorphisms (SNPs) testing on an existing clinical risk calculator in prostate cancer patients. https://hdl.handle.net/2078.5/79718