Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies
(2011) PLoS One — Vol. 6, n° 10, p. e26311 [1-9] (2011)
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- et. al.
- Abstract
- Fluorescence in situ hybridization was performed to characterize 81 cases of myeloid and lymphoid malignancies with cytogenetic 1p36 alterations not affecting the PRDM16 locus. In total, three subgroups were identified: balanced translocations (N = 27) and telomeric rearrangements (N = 15), both mainly observed in myeloid disorders; and unbalanced non-telomeric rearrangements (N = 39), mainly observed in lymphoid proliferations and frequently associated with a highly complex karyotype. The 1p36 rearrangement was isolated in 12 cases, mainly myeloid disorders. The breakpoints on 1p36 were more widely distributed than previously reported, but with identifiable rare breakpoint cluster regions, such as the TP73 locus. We also found novel partner loci on 1p36 for the known multi-partner genes HMGA2 and RUNX1. We precised the common terminal 1p36 deletion, which has been suggested to have an adverse prognosis, in B-cell lymphomas [follicular lymphomas and diffuse large B-cell lymphomas with t(14;18)(q32;q21) as well as follicular lymphomas without t(14;18)]. Intrachromosomal telomeric repetitive sequences were detected in at least half the cases of telomeric rearrangements. It is unclear how the latter rearrangements occurred and whether they represent oncogenic events or result from chromosomal instability during oncogenesis.
- Affiliations
CHU de Liège Center for Human Genetics CHU de Nice Center for Human Genetics KULeuven Center for Human Genetics CHU de Lille Center for Human Genetics CHU de Montpellier Center for Human Genetics Groupe Hospitalier Pitié-Salpétrière Center for Human Genetics Hôpital Purpan, Toulouse Center for Human Genetics CHU de Bordeaux Center for Human Genetics UZ Ghent Center for Human Genetics IPG Center for Human Genetics CHU de Nantes Center for Human Genetics CHU de Dijon Center for Human Genetics Centre Hospitalier Lyon Sud Center for Human Genetics Institut Paoli-Calmettes Center for Human Genetics CHU Hôpital Nord, Saint-Etienne Center for Human Genetics Centre Hospitalier de Versailles Center for Human Genetics
Citations
Duhoux, F., Ameye, G., Lambot, V., Herens, C., Labis, E., Terré, C., Nadal, N., Laibe, S., Mozziconacci, M.-J., Raynaud, S., Wlodarska, I., Michaux, L., Roche-Lestienne, C., Libouton, J.-M., Decottignies, A., Taviaux, S., Chapiro, E., Nguyen Khac, F., Struski, S., et al. (2011). Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies. PLoS One, 6(10), e26311 [1-9]. https://hdl.handle.net/2078.5/92990 (Original work published 2011)