Outcome Following Organ Removal From Poisoned Donors - Experience With 12 Cases and a Review of the Literature
(1995) Transplant International — Vol. 8, n° 3, p. 185-189 (1995)
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- Abstract
- From 1975 to 1993, our University Hospital performed 2789 graft procedures. During the same period, 12 poisoned, ''brain-dead'' patients were considered as organ donors. The toxic substances involved were: methaqualone (n = 1), benzodiazepine alone (n = 1), benzodiazepine plus tricyclic antidepressants (n = 1), tricyclic antidepressants alone (n = 1), barbiturates (n = 2), insulin (n = 2), carbon mon oxide (n = 1), cyanide (n = 1), methanol (n = 1), and acetaminophen (n = 1). From these intoxicated persons, 32 organ transplants were obtained, but only 23 could be followed for 1 month and only 20 for 1 pear, The outcome at 1 month was favorable in 20 of the 23 patients. Two heart transplant patients died within 24 h after grafting from stroke and acute heart failure, respectively. Preoperative hepatic encephalopathy was not corrected after grafting and was directly responsible for the death of a liver transplant patient. After 1 year, 15 of the 20 recipients were still alive. Chronic hepatic graft rejection led to a fatal outcome in one recipient and to second grafting in another. Finally, one recipient died from delayed neoplasia. Based on our experience, organ procurement may be considered in a few select cases of acute poisoning. Attention should, however, be drawn to possible graft damage due to some poisons.
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Citations
Hantson, P., Vekemans, MC., Squifflet, J.-P., & Mahieu, P. (1995). Outcome Following Organ Removal From Poisoned Donors - Experience With 12 Cases and a Review of the Literature. Transplant International, 8(3), 185-189. https://doi.org/10.1111/j.1432-2277.1995.tb01501.x (Original work published 1995)