The leader protein of Theiler's virus interferes with nucleocytoplasmic trafficking of cellular proteins.

Delhaye, Sophie;Van Pesch, Vincent;Michiels, Thomas
(2004) Journal of Virology — Vol. 78, n° 8, p. 4357-4362 (2004)

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The leader protein of Theiler's virus was previously shown to block the production of alpha/beta interferon by infected cells. Here, we observed that expression of the leader protein in infected cells triggered subcellular redistribution of a nucleus-target green fluorescent protein. It enhanced redistribution of the nuclear polypyrimidine tract-binding protein but had no influence on the localization of the nuclear splicing factor SC-35. The leader protein also interfered with trafficking of the cytoplasmic interferon regulatory factor 3, a factor critical for transcriptional activation of alpha/beta interferon genes.
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Delhaye, S., Van Pesch, V., & Michiels, T. (2004). The leader protein of Theiler’s virus interferes with nucleocytoplasmic trafficking of cellular proteins. Journal of Virology, 78(8), 4357-4362. https://doi.org/10.1128/JVI.78.8.4357-4362.2004 (Original work published 2004)