Analysis of new biodegradable amphiphilic water-soluble copolymers with various hydrophobe content by multi-angle light scattering on line with flow field flow fractionation

Glinel, Karine;Vaugelade, C;Muller, G;Bunel, C
(2000) International Journal of Polymer Analysis and Characterization — Vol. 6, n° 1-2, p. 89-107 (2000)

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  • Glinel, Karineorcid-logoUCL; Laboratoire Polymères, Biopolymères, Membranes, UMR 6522 CNRS, Université de Rouen, Mont-Saint-Aignan, France
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  • Vaugelade, C
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  • Muller, G
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  • Bunel, C
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Abstract
Flow field flow fractionation (F4) with an on-line multi-angle laser light scattering detector was used to characterize amphiphilic biodegradable water-soluble copolymers poly(methyl glyoxylate -co- potassium glyoxylate). These new products are prepared from hydrophobic poly(methyl glyoxylate) by partial and statistical saponification of methyl ester functions. Conformational shape and degradability of polymers in dilute aqueous solution were investigated as a function of saponification rate (y) ranged from 10 to 100%. Derivatives with high hydrophobe content (y=10%) forms compact intermolecular aggregates. In contrast, macromolecules of poly(potassium glyoxylate) (y = 100%) are molecularly dispersed in solution because of the presence of numerous electrostatic repulsions. For intermediate compounds(15 less than or equal to y less than or equal to 81%), the major part of the sample is represented by a population of single polymer molecules dispersed in solution. The kinetics of degradation of these different copolymers in aqueous solution was found to be a direct function of the macromolecular conformation and the percentage of methyl ester groups on the polymer chains.
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Glinel, K., Vaugelade, C., Muller, G., & Bunel, C. (2000). Analysis of new biodegradable amphiphilic water-soluble copolymers with various hydrophobe content by multi-angle light scattering on line with flow field flow fractionation. International Journal of Polymer Analysis and Characterization, 6(1-2), 89-107. https://doi.org/10.1080/10236660008034652 (Original work published 2000)