Immobilization of thrombin inhibitors on polyesters surface: an original approach towards materials blood compatibilization
(2006) Materials Science Forum — Vol. 514-516, p. 961-965 (2006)
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- Abstract
- Piperazinyl-amide derivatives of N-alpha-(3-trifluoromethyl-benzenesulfonyl)-L-arginine were synthesized as graftable thrombin inhibitors, Their biological activity was evaluated in vitro, against human alpha-thrombin, and in blood coagulation assay. The piperazinyl-amide derivatives were found to inhibit the activity of a-thrombin in the micromolar range. The designed molecules were fixed on poly(ethylene terephthalate) (PET), and poly(butylene terephthalate) (PBT) by wet chemistry treatment (activation of hydroxyl chain-ends) and photochemistry (nitrene insertion by photoactivation of aromatic azide). The protocols were validated by X-ray photoelectron spectroscopy (XPS) and by radiochemical assay (liquid scintillation counting, LSC).
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Salvagnini, C., & Marchand-Brynaert, J. (2006). Immobilization of thrombin inhibitors on polyesters surface: an original approach towards materials blood compatibilization. Materials Science Forum, 514-516, 961-965. https://doi.org/10.4028/www.scientific.net/MSF.514-516.961 (Original work published 2006)